A causal inference approach for constructing transcriptional regulatory networks
نویسندگان
چکیده
منابع مشابه
A causal inference approach for constructing transcriptional regulatory networks
MOTIVATION Transcriptional regulatory networks specify the interactions among regulatory genes and between regulatory genes and their target genes. Discovering transcriptional regulatory networks helps us to understand the underlying mechanism of complex cellular processes and responses. METHOD This paper describes a causal inference approach for constructing transcriptional regulatory networ...
متن کاملConstructing transcriptional regulatory networks.
Biological networks are the representation of multiple interactions within a cell, a global view intended to help understand how relationships between molecules dictate cellular behavior. Recent advances in molecular and computational biology have made possible the study of intricate transcriptional regulatory networks that describe gene expression as a function of regulatory inputs specified b...
متن کاملImproving the Inference of Gene Expression Regulatory Networks with Data Aggregation Approach
Introduction: The major issue for the future of bioinformatics is the design of tools to determine the functions and all products of single-cell genes. This requires the integration of different biological disciplines as well as sophisticated mathematical and statistical tools. This study revealed that data mining techniques can be used to develop models for diagnosing high-risk or low-risk lif...
متن کاملBoosting the Performance of Inference Algorithms for Transcriptional Regulatory Networks Using a Phylogenetic Approach
Inferring transcriptional regulatory networks from gene-expression data remains a challenging problem, in part because of the noisy nature of the data and the lack of strong network models. Time-series expression data have shown promise and recent work by Babu on the evolution of regulatory networks in E. coli and S. cerevisiae opened another avenue of investigation. In this paper we take the e...
متن کاملA causal mapping approach to constructing Bayesian networks
..................................................................................................................................... 1
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti648